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Sibutramine, Oral

What are other names for this medicine?

Type of medicine: appetite suppressant

Generic and brand names: sibutramine, oral; Meridia

What is this medicine used for?

This medicine is taken by mouth to help you lose weight and not gain back the weight you lose. You must also follow a reduced-calorie diet and a regular exercise program.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

  • an allergic reaction to any medicine
  • a bleeding disorder
  • a stroke
  • an eating disorder
  • depression, bipolar disorder, or other mood disorder
  • gallstones or gallbladder disease
  • glaucoma
  • heart disease
  • high blood pressure
  • liver or kidney disease
  • migraines
  • problems with substance abuse
  • seizures
  • thyroid problems

Tell your provider about all the medicines you take. Do not take this medicine if you have taken an MAO inhibitor in the past 14 days. Do not take other weight loss medicines, including herbal weight loss medicines or supplements, while you are taking this medicine.

Females of childbearing age: Tell your healthcare provider if you are pregnant or intend to become pregnant while taking this medicine. Do not take this medicine if you are pregnant. Use an effective method of birth control, and do not breast-feed while you are taking this medicine without your healthcare provider's approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as directed by your healthcare provider. Do not take more or take it for a longer period than directed. Taking too much may be habit-forming. Talk with your healthcare provider about how long you can take this medicine.

Read the information sheet that comes in the medicine package before you start to take it this medicine and every time you have your prescription refilled.

You may take this medicine with or without food. If you have trouble sleeping while taking this medicine, try taking it in the morning.

What if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

If you or anyone else has intentionally taken too much of this medicine, call 911 or go to the emergency room right away. If you pass out, have seizures, weakness or confusion, or have trouble breathing, call 911. If you think that you or anyone else may have taken too much of this medicine, call the poison control center. Do this even if there are no signs of discomfort or poisoning. The poison control center number is 800-222-1222.

Symptoms of an acute overdose may include: fast heartbeat, dizziness, headache.

 
 

What should I watch out for?

Your healthcare provider will want to check you regularly. This medicine may cause your pulse rate and blood pressure to rise, so your dosage may need to be adjusted.

If you do not lose at least 4 pounds in the first 4 weeks, and you have been following a reduced calorie diet, contact your healthcare provider. Your dosage may need to be adjusted.

Other weight-loss medicines may lead to pulmonary hypertension (high pressure in the blood vessels of the lungs). This is a rare but sometimes deadly disease. This medicine (sibutramine) has not been known to cause this problem, but the possibility may exist. The symptoms or pulmonary hypertension include new or worsening shortness of breath, chest pain, fainting, or swelling of your feet, ankles, or legs. Talk with your healthcare provider about this.

This medicine may make you dizzy or drowsy. Do not drive or operate machinery unless you are fully alert.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

Do not drink alcohol unless your healthcare provider approves.

This medicine is a controlled substance. It is illegal to give it to anyone else.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Chest pain; severe increase in blood pressure; shortness of breath; fast, pounding, or irregular heart beat; restlessness; lightheadedness; severe confusion; loss of muscle coordination; tremors; unexplained muscle stiffness; eye pain; high fever; sweating; depression; stomach pain; vomiting; unusual bleeding or bruising; seizures.

Other: Headache, dry mouth, trouble sleeping, constipation, diarrhea, runny nose, nausea, back pain, menstrual problems, dizziness.

 
 

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), trazodone (Desyrel), mirtazapine (Remeron), bupropion (Wellbutrin), maprotiline (Ludiomil), nefazodone, amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), and doxepin (Sinequan)
  • dextromethorphan (DM), an ingredient in many cough medicines
  • ephedrine or pseudoephedrine (in many cough, cold, and allergy medicines)
  • antibiotics such as erythromycin (Erythrocin, E.E.S., EryPed, Ery-Tab, Ilotycin) and linezolid (Zyvox)
  • antifungal medicines such as ketoconazole (Nizoral)
  • herbal medicines such as St. John's Wort, Ma huang, or ephedra
  • lithium (Lithobid)
  • MAO inhibitor medicines such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), and tranylcypromine (Parnate) (Do not take an MAO inhibitor and this medicine within 14 days of each other.)
  • medicines to treat headaches such as almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), zolmitriptan (Zomig), dihydroergotamine (Migranal, D.H.E. 45), and ergotamine (Ergomar)
  • medicines that may increase risk of bleeding such as aspirin, warfarin (Coumadin), ticlopidine (Ticlid), dipyridamole (Persantine), and clopidogrel (Plavix)
  • other appetite suppressant or stimulant medicines such as benzphetamine (Didrex), dextroamphetamine (Ferndex, Dexedrine), diethylpropion (Tenuate), phendimetrazine (Bontril, X-trozine), methamphetamine hydrochloride (Desoxyn), and phentermine (Ionamin, Adipex-P)
  • pain medicines such as fentanyl (Actiq, Duragesic, Sublimaze), meperidine (Demerol), and pentazocine (Talwin)
  • procarbazine (Matulane)
  • tryptophan (L-Tryptophan, Trofan)

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), trazodone (Desyrel), mirtazapine (Remeron), bupropion (Wellbutrin), maprotiline (Ludiomil), nefazodone, amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), and doxepin (Sinequan)
  • dextromethorphan (DM), an ingredient in many cough medicines
  • ephedrine or pseudoephedrine (in many cough, cold, and allergy medicines)
  • antibiotics such as erythromycin (Erythrocin, E.E.S., EryPed, Ery-Tab, Ilotycin) and linezolid (Zyvox)
  • antifungal medicines such as ketoconazole (Nizoral)
  • herbal medicines such as St. John's Wort, Ma huang, or ephedra
  • lithium (Lithobid)
  • MAO inhibitor medicines such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), and tranylcypromine (Parnate) (Do not take an MAO inhibitor and this medicine within 14 days of each other.)
  • medicines to treat headaches such as almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), zolmitriptan (Zomig), dihydroergotamine (Migranal, D.H.E. 45), and ergotamine (Ergomar)
  • medicines that may increase risk of bleeding such as aspirin, warfarin (Coumadin), ticlopidine (Ticlid), dipyridamole (Persantine), and clopidogrel (Plavix)
  • other appetite suppressant or stimulant medicines such as benzphetamine (Didrex), dextroamphetamine (Ferndex, Dexedrine), diethylpropion (Tenuate), phendimetrazine (Bontril, X-trozine), methamphetamine hydrochloride (Desoxyn), and phentermine (Ionamin, Adipex-P)
  • pain medicines such as fentanyl (Actiq, Duragesic, Sublimaze), meperidine (Demerol), and pentazocine (Talwin)
  • procarbazine (Matulane)
  • tryptophan (L-Tryptophan, Trofan)

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

____________________________________________________

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your healthcare provider if you are taking:

  • alcohol
  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), trazodone (Desyrel), mirtazapine (Remeron), bupropion (Wellbutrin), maprotiline (Ludiomil), nefazodone, amitriptyline, nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), and doxepin (Sinequan)
  • dextromethorphan (DM), an ingredient in many cough medicines
  • ephedrine or pseudoephedrine (in many cough, cold, and allergy medicines)
  • antibiotics such as erythromycin (Erythrocin, E.E.S., EryPed, Ery-Tab, Ilotycin) and linezolid (Zyvox)
  • antifungal medicines such as ketoconazole (Nizoral)
  • herbal medicines such as St. John's Wort, Ma huang, or ephedra
  • lithium (Lithobid)
  • MAO inhibitor medicines such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl), and tranylcypromine (Parnate) (Do not take an MAO inhibitor and this medicine within 14 days of each other.)
  • medicines to treat headaches such as almotriptan (Axert), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), zolmitriptan (Zomig), dihydroergotamine (Migranal, D.H.E. 45), and ergotamine (Ergomar)
  • medicines that may increase risk of bleeding such as aspirin, warfarin (Coumadin), ticlopidine (Ticlid), dipyridamole (Persantine), and clopidogrel (Plavix)
  • other appetite suppressant or stimulant medicines such as benzphetamine (Didrex), dextroamphetamine (Ferndex, Dexedrine), diethylpropion (Tenuate), phendimetrazine (Bontril, X-trozine), methamphetamine hydrochloride (Desoxyn), and phentermine (Ionamin, Adipex-P)
  • pain medicines such as fentanyl (Actiq, Duragesic, Sublimaze), meperidine (Demerol), and pentazocine (Talwin)
  • procarbazine (Matulane)
  • tryptophan (L-Tryptophan, Trofan)

Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

____________________________________________________

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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IDLI versus VADA
 
 
 
 
 
 



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